Mexican
Guadalupe on Main
Mesa, Arizona
Why stop here: Guadalupe on Main is a $$ mexican pick in Mesa. Order Birria tacos with the house margarita.
CuisineMexican
Price$$
TownMesa
Jalisco-inspired Mexican on Main Street that swept Phoenix Magazine's 2025 Best New Restaurant and Best Mexican honors, with live music on Sundays.
What to order
Birria tacos with the house margarita
Updated 2026-07-01. Restaurant hours, menus, and reservation policies change — confirm before you go.
Build a trip around Mesa dining stop.
Roamward turns spots like this into a real road trip on your phone — the scenic drive, the stops, and the detours, planned around the vibe you’re after. Get early access: